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Monday, May 4, 2020 | History

4 edition of Electrical field coupling of smooth muscle cells in the gastrointestinal tract found in the catalog.

Electrical field coupling of smooth muscle cells in the gastrointestinal tract

Edward Joseph Vigmond

Electrical field coupling of smooth muscle cells in the gastrointestinal tract

by Edward Joseph Vigmond

  • 193 Want to read
  • 25 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.A.Sc.)--University of Toronto, 1991.

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches.
ID Numbers
Open LibraryOL19298239M
ISBN 100315654449
OCLC/WorldCa46527777

ISBN: OCLC Number: Description: 1 online resource: Contents: PART I: Gastrointestinal tract --Phasic muscle --Spontaneous electrical activity and rhythmicity in gastrointestinal smooth muscles --Tonic muscle (Sphincters) --Generation of tone by gastrointestinal sphincters --PART II: Urinary tract --Renal pelvis --Pacemaker mechanisms driving pyeloureteric. Biomechanics of the Gastrointestinal Tract is an up-to-date book for researchers on the study of the mechanical properties and the motor system of the gastrointestinal tract. A well-illustrated book, it provides a comprehensive overview to relevant tissue geometry, morphology and biomechanical by:

PHYSIOLOGY OF THE GASTROINTESTINAL TRACT (GIT) Main function: The GIT provides the body with a supply of water, nutrients, electrolytes, vitamines. Gastric slow waves – basal electric rhythm – 3/min – pacemaker cells – the circular smooth muscle of the fundus Velocity – 1- 4 cm/s – weak propulsion to move the chyme toward the. Introduction. The gastrointestinal (GI) tract, as the body's largest hollow-organ system, is constantly subjected to mechanical stimuli (Shi et al., ).On the one hand, gut smooth muscle generates three types of contracting forces, i.e., tone, rhythmic phasic contraction, and giant migrating contraction (Sarna and Shi, ).The main functions of these contractile activities are to Cited by: 5.

GI physiology review Autonomous smooth muscle function Intestinal smooth muscle cells: effector organ of GI motility Pacemaker activity: Thin layer of interstitial cells (interstitial cells of Cajal) between circular and longitudinal cell layer. Conduction through gap junctions. A comprehensive and systematic survey of the present knowledge of the structure and physiological functions of smooth muscle and its response to endogenous substances and pharmacological agents. The latter includes findings on different organ systems containing smooth muscle - with the exception of the vascular system which, owing to the great amount of new knowledge accumulated in this area.


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Electrical field coupling of smooth muscle cells in the gastrointestinal tract by Edward Joseph Vigmond Download PDF EPUB FB2

IM-ICCs in the circular muscle layers are electrically coupled via gap junctions to smooth muscle cells. The action potentials generated by the smooth muscle in the GI tract are slower & longer vs. Field coupling Electrical control activity Excitable cells Gap junctions Cellular morphology Boundary element method Electrical coupling Gastrointestinal smooth muscle This is a preview of subscription content, log in to check by: 4.

Angela Wirth, Stefan Offermanns, in Muscle, Smooth muscle cells in the wall of many hollow organs like the bronchial, vascular, gastrointestinal or urogenital system, play a central role in organ function under physiological and pathophysiological conditions.

The tone of smooth muscle cells is under the control of numerous factors that are produced and released locally as well as. Gastrointestinal Motility and Smooth Muscle Early in life, children notice that strange gurgling sounds sporadically emanate from their "stomachs," particularly in periods between meals.

This simple observation reflects the fact that the digestive tube is quite muscular and that muscle contractions and motility are integral parts of digestive.

BULBRING E. Membrane potentials of smooth muscle fibres of the taenia coli of the guinea-pig. J Physiol. Aug 27; (2)– [PMC free article] BURNSTOCK G, STRAUB RW.

A method for studying the effects of ions and drugs on the resting and action potentials in Cited by: Electrophysiology of Gastrointestinal Smooth Muscle.

Normal gastrointestinal motility results from coordinated contractions of smooth muscle, which in turn derive from two basic patterns of electrical activity across the membranes of smooth muscle cells - slow waves and spike potentials.

Like other excitable cells, gastrointestinal smooth muscle cells maintain a electrical potential difference. Interstitial cells of mesenchymal origin interact with and form electrical connectivity with smooth muscle cells in many organs, and these cells provide important regulatory functions.

For example, in the gastrointestinal tract, interstitial cells of Cajal (ICC) and PDGFRα(+) cells have been described, in detail, and represent distinct classes Cited by: Interstitial cells of Cajal (ICC) regulate smooth muscle excitability and motility in the gastrointestinal (GI) tract.

ICC in the deep muscular plexus (ICC-DMP) of the small intestine are aligned. This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets.

Muscle contractions can be described based on two variables: force and length. Force itself can be differentiated as either tension or load. Muscle tension is the force exerted by the muscle on an object whereas a load is the force exerted by an object on the muscle.

When muscle tension changes without any corresponding changes in muscle length, the muscle contraction is described as isometric.

musculomembranous tube (30 ) extending from mouth to anus. aka digestive tract or gastrointestinal tract absorption passage of substances across and into tissues such as the passage of digested food molecules into intestinal cells or the passage of liquids into kidney tubules.

Results indicate that even small gap junctional conductances are effective for coupling of smooth muscle and that field coupling is most efficacious when the ellipsoidal cells are coupled side by Author: Nicholas Sperelakis. However, in comparison to other excitable cell types, little is known about the coupling mechanisms whereby peptide-receptor binding alters ion channel activity in gastrointestinal smooth muscle.

This represents one of the challenging areas to be studied in the field of gastrointestinal smooth by: 9. FROM THE PREFACE: The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect in one set of volumes the most current and comprehensive knowledge in our field—was also the driving force for the Fourth explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques.

Smooth muscle cells also develop tonic and phasic contractions in response to changes in load or length. Regardless of the stimulus, smooth muscle cells use cross-bridge cycling between actin and myosin to develop force, and calcium ions (Ca 2+) serve to initiate by: 1.

Electrical communication between circular muscle, longitudinal muscle and interstitial cells of Cajal (ICC) was investigated; the hypothesis was tested that the resting membrane potential (RMP) gradient in the circular muscle of canine colon is caused by electrical coupling to neighbouring by: Regulation of Excitation -Contraction and Excitation-Transcription Coupling in Gastrointestinal Smooth Muscle by Caveolin A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth Univer sity.

Sayak Bhattacharya. in Physiology, University of Calcutta, : Sayak bhattacharya. Electrical Activity of Gastrointestinal Smooth Muscle. Voltage of the resting membrane potential of the gastrointestinal smooth muscle can be made to change to different levels.

Complex interactions among the smooth muscle cells and specialized cells Interstitial cells of Cajal - pacemaker cells. 9 / Cellular Physiology of Skeletal, Cardiac, and Smooth Muscle Some Smooth Muscle Cells Can Initiate Spontaneous Electrical Activity Although smooth muscle cells undergo changes in V rn in response to neural, hormonal, or mechanical stimulation, many smooth muscle cells are capable of initiating spon-taneous electrical activity.

Regulation of gastrointestinal (GI) motility is intimately coordinated with the modulation of ionic conductances expressed in GI smooth muscle and nonmuscle cells. Interstitial cells of Cajal (ICC) act as pacemaker cells and possess unique ionic conductances that trigger slow wave activity in these cells.

The slow wave mechanism is an exclusive feature of ICC: Smooth muscle cells may lack the Cited by:. The properties of smooth muscle are currently being studied extensively.

Indeed, the small size of myocytes and the huge range of behaviours they exhibit make them an attractive focus for current research. However, this was not always the case. These properties initially made smooth muscles more difficult to study than the larger specialized striated muscles that were the focus of attention of Cited by: 4.Buy Biomechanics of the Gastrointestinal Tract: New Perspectives in Motility Research and Diagnostics: Read Books Reviews - ed by:   Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.

The gastrointestinal system is responsible for the Book Edition: 5.